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KMID : 1161420180210020203
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Journal of Medicinal Food
2018 Volume.21 No. 2 p.203 ~ p.206
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A Blend of Extracts from Houttuynia cordata, Nelumbo nucifera, and Camellia sinensis Protects Against Ethanol-Induced Liver Damage in C57BL/6 Mice
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You Yang-Hee
Lee Hyun-Mi
Yoon Ho-Geun
Park Jeong-Jin
Kim Ok-Kyung
Kim Kyung-Mi
Lee Min-Jae
Lee Yoo-Hyun
Lee Jeong-min
Jun Woo-Jin
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Abstract
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The protective activity of a mixture of aqueous and ethanolic extracts from Houttuynia cordata Thunb, Nelumbo nucifera G. leaves, and Camellia sinensis seed (HNC) was evaluated in C57BL/6 mice. Pretreatment with HNC prevented the elevation of serum aspartate aminotransferase and alanine aminotransferase caused by ethanol-induced hepatic damage. The HNC-treated mice showed significantly lower triglyceride levels, reduced CYP2E1 activity, and increased antioxidant enzyme activities and lipogenic mRNA levels. These results suggest that HNC might be a candidate agent for liver protection against ethanol-induced oxidative damage, through enhancement of antioxidant and antilipogenic activity.
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KEYWORD
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Camellia sinensis, ethanol, Houttuynia cordata Thunb, liver damage, Nelumbo nucifera G.
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